A postdoctoral position is immediately available in the lab of Dr. Bo Zhao, at Indiana University School of Medicine(http://www.indiana.edu/~zhaolab/index.html), to study the underlying mechanisms of auditory perception and deafness. The successful applicant will employ biochemistry, immunohistochemistry and/or mouse genetics approaches to identify molecules and pathways that regulate the morphogenesis and functions of sensory hair cells, the primary receptors for sound.
We are particularly looking for a highly motivated and creative candidate with a Ph.D. degree (within three years) in cell biology, biochemistry, neuroscience, or a closely related field. Individuals with a strong methodological background in protein purification, molecular biology, biochemistry, mouse genetics or microscope imaging are highly encouraged to apply. The candidate must also have excellent interpersonal, organizational, communication and writing skills. To apply, please send CV, cover letter and 2-3 contacts for references to Dr. Bo Zhao (zhaozb@iupui.edu).
1. Bo Zhao*, Zizhen Wu and Ulrich Müller. Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.eLife2016 Jun 8;5.
2. Bo Zhao*, Ulrich Müller. The Elusive Mechanotransduction Machinery of Hair Cells: Molecules and Models.Curr Opin Neurobiol2015; 34:172-79.
3. Bo Zhao*, Zizhen Wu, Nicolas Grillet, Linxuan Yan, Wei Xiong, Sarah Harkins-Perry and Ulrich Müller. TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.Neuron2014; 84:954-67.
4. Clive P. Morgan*, Jocelyn F. Krey*, M'hamed Grati,Bo Zhao, Shannon Fallen, Abhirami Kannan-Sundhari, Xue Zhong Liu, Dongseok Choi, Ulrich Müller, and Peter G. Barr-Gillespie. PDZD7-MYO7A complex identified in enriched stereocilia membranes.eLife2016 Aug 15; 5.
5. Maryline Beurg*, Wei Xiong,Bo Zhao, Ulrich Müller and Robert Fettiplace. Subunit determination of the conductance of hair-cell mechanotransducer channels.Proc Natl Acad Sci U S A2015; 112(5):1589-94.
6. Wei Xiong*, Nicolas Grillet, Heather M. Elledge,Thomas F.J. Wagner,Bo Zhao, Kenneth R. Johnson, Piotr Kazmierczak and Ulrich Müller. TMHS is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells.Cell2012; 151: 1283–1295.
Bo Zhao, PhD
Assistant Professor of Otolaryngology-Head & Neck Surgery
Bo Zhao, PhD, was appointed Assistant Professor of Otolaryngology-Head & Neck Surgery in December 2016. He joined the IU School of Medicine after working with Dr. Ulrich Müller at The Scripps Research Institute in La Jolla, California. With a doctorate in Neurobiology, Dr. Zhao is most interested to identify novel molecules and pathways required for auditory perceptions. His research goal is to develop new therapeutic treatment for some forms of sensorineural hearing loss, caused by defects in cochlear hair cells.
Dr. Zhao recently received funding from the National Institute on Deafness and Other Communication Disorders (NIDCD) for his research, entitled “Fam65b function in hearing and deafness.” He continues his research in the Laboratory of Molecular Mechanisms of Auditory Perception and Deafness, located in the Glick Eye Institute on the IUPUI campus.
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